Exogenous itaconate addition in apolipoprotein E-deficient (Apoe−/−) mice suppressed the initiation and development of AAA and downstream inflammatory protein though Irg1 deficiency reverted the outcome of inhibitory. Overexpression of Keap1 or transferred Cys151S mutant Keap1 vector also abolished the activation of Nrf2 induced by itaconate.Th
Three biological replicates for every affliction and two for IgG backgrounds. Peaks were classified as special if happened in isolation, or reoccurring if overlapped with a minimum of 1 other peaks±500 bp. Error bars depict the array of peak numbers for three biological replicates. The exact peak numbers are proven in Supplementary Tables 8 and
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